abstract：:N-1 methylation of benzo-alpha-carbolines performed with Kitasatosporia setae strain yields corresponding benzo-alpha-iso-carbolines, compounds demonstrating relatively strong cytostatic and antitumor properties. To obtain radioactive benzo-alpha-iso-carbolines required for the further studies of their mode of antitum...

journal_title：Archivum immunologiae et therapiae experimentalis

authors： Peczyńska-Czoch W

更新日期：1987-01-01 00:00:00

abstract：:alpha-Carboline derivatives substituted with methyl groups at C-2, C-4, C-2,4, C-6 and C-8 position were subjected to N-1 methylation performed by Kitasatosporia setae. The yield of formed corresponding alpha-iso-carbolines varied, depending on the position of methyl substituent. It has been observed that the methyl g...

journal_title：Archivum immunologiae et therapiae experimentalis

authors： Peczyńska-Czoch W

更新日期：1987-01-01 00:00:00

abstract：:It was demonstrated that human, recombinant Il-1 significantly inhibited formation of autologous rosettes by thymocytes. In addition, Il-1 increased the percentage of thymocytes resistant to hydrocortisone. Il-2 was not active in both tests. A new method of determination of Il-1 activity, based on the inhibition of th...

journal_title：Archivum immunologiae et therapiae experimentalis

authors： Zimecki M,Wieczorek Z

更新日期：1987-01-01 00:00:00

abstract：:The mesenteric and pulmonary mast cells of guinea pigs were obtained by enzymatic dispersion of the tissues with the enzyme collagenase. The guinea pig mast cells obtained by this method were morphologically intact, as judged by light microscopy. The mast cells from lung and mesentery of actively sensitized guinea pig...

journal_title：Archivum immunologiae et therapiae experimentalis

authors： Brezezińska-Błaszczyk E,Czuwaj M,Wyczółkowska J

更新日期：1987-01-01 00:00:00

abstract：:The results of treatment with intrauterine transfusion are presented. The analysis comprised 48 successful transfusions into 29 foetuses. The reference group consisted of 11 transfusions which proved nonfeasible or ineffective and 54 untreated cases. Following blood treatment, the newborn mortality rate dropped more t...

journal_title：Archivum immunologiae et therapiae experimentalis

authors： Lozińska D,Radomska I,Niedzicka E,Dmoch E,Czerwoniec W

更新日期：1987-01-01 00:00:00

abstract：:In reactions of 5-aminoisothiazolopyrimidines 1 with glycosilisothiocyanates and phenyl isocyano- or isocyanates, N-glycosilo-N-phenylo- and N-isothiazolopyrimidinothiocarbamides type II were obtained. The same compound--5-aminoisothiazolopyrimidine 1 in reaction with glucose, arabinose and ribose bromoderivatives was...

journal_title：Archivum immunologiae et therapiae experimentalis

authors： Machoń Z,Mielczarek I,Wieczorek J,Mordarski M

更新日期：1987-01-01 00:00:00

abstract：:Fresh porcine blood platelets, subjected to ethanol acid extraction and purification on DEAE-Sephadex A-50 and CM-Sephadex C-50, were used to obtain partially purified, cationic PDGF (pI 8.5-10) of Mr 38,000 and biological activity 10(4) U/ml. Reduction of porcine PDGF with 2-mercaptoethanol revealed the presence of t...

journal_title：Archivum immunologiae et therapiae experimentalis

authors： Narczewska B,Czyrski JA

更新日期：1987-01-01 00:00:00

abstract：:Tissue distribution of non-Lyt1.1 ("Ly10-like") antigen or antigens encoded by short chromosomal segment differentiating B6-Ly-1a congenic strain from B6 strain of mice was studied by quantitative absorption of (BALB/c X B6)F1 anti B6-Ly-1a antiserum and by direct cytotoxicity of Ly-10-132-12-26 monoclonal antibody on...

journal_title：Archivum immunologiae et therapiae experimentalis

authors： Kuśnierczyk P,Wysocka M,Szkudlarek J,Steuden I,Szymaniec S,Kisielow P

更新日期：1986-01-01 00:00:00

abstract：:Glycogen-protein complexes from the muscles of Celerio euphorbiae and horse as well as from the livers of frog, carp and man were isolated and used as antigens. After immunization of rabbits antisera were obtained from which fractions of immunoglobulins were isolated. Antibodies were used in agar immunodiffusion tests...

journal_title：Archivum immunologiae et therapiae experimentalis

authors： Sobiech KA,Karpiak SE

更新日期：1986-01-01 00:00:00

abstract：:Comparison of pharmacological properties of commercial racemic Cyclophosphamide and its D- and L-enantiomers was performed in experiments on mice and rats. Acute toxicity, behavioral screening tests and the effects of subchronic treatment (influence on body mass, the increase of the mass of internal organs, mortality,...

journal_title：Archivum immunologiae et therapiae experimentalis

authors： Kleinrok Z,Chmielewska B,Czuczwar JS,Kozicka M,Rajtar G,Jarzabek G,Sawiniec Z

更新日期：1986-01-01 00:00:00

abstract：:Spotted souslik's interferon beta (So IFN beta), bovine interferon beta (Bov IFN beta) and mouse IFN beta/a were purified on Controlled Pore Glass (CPG) using original CPG, not modified, and CPG with boron enriched surface. The surface boron atoms enrichment of CPG lead to higher selectivity of interferon binding and ...

journal_title：Archivum immunologiae et therapiae experimentalis

authors： Kandefer-Szerszeń M,Kaczor J,Dawidowicz A

更新日期：1986-01-01 00:00:00

abstract：:A suspension of resident peritoneal cells isolated from individual Balb/c mice was subjected to gradual separation into the cells adherent and nonadherent to glass. The isolated fast adherent fraction displayed regulatory properties in relation to spontaneous interferon synthesis. Depending on whether the cells come f...

journal_title：Archivum immunologiae et therapiae experimentalis

authors： Błach-Olszewska Z

更新日期：1986-01-01 00:00:00

abstract：:Lyt phenotypes of interleukin-2 and interferon producing Balb/c cortisone resistant thymocytes, stimulated by concanavalin A in vitro, were studied using cytotoxic anti-Lyt-1.2 and anti-Lyt-2.2 alloantisera and monoclonal antibodies. It was found that while interleukin-2 was produced by both Lyt1+ and Lyt2+ cells, the...

journal_title：Archivum immunologiae et therapiae experimentalis

authors： Pajtasz E,Kuśnierczyk P,Albin M,Kisielow P

更新日期：1986-01-01 00:00:00

abstract：:Eleven mycoplasma strains were isolated from the semen of 24 stallions. Eight of these strains were identified as Mycoplasma equigenitalium. Three strains which hydrolized arginine could not be identified. The growth inhibition test with immune sera against M. arginini and M. equirhinis was negative. Antibiotic sensit...

journal_title：Archivum immunologiae et therapiae experimentalis

authors： Zgórniak-Nowosielska I,Kosiniak K,Slagowska A

更新日期：1985-01-01 00:00:00

abstract：:Anti-IgE and antigen-induced histamine release from basophils isolated from 30 atopic patients sensitive to grass pollen allergens was evaluated. The studies were made before and after short-term immunotherapy with glutaraldehyde-pollen-tyrosine adsorbate (Pollinex). It was shown, that after immunotherapy a significan...

journal_title：Archivum immunologiae et therapiae experimentalis

authors： Chyrek-Borowska S,Kuczewska B,Hofman J,Szymański W,Lukaszewicz D

更新日期：1985-01-01 00:00:00

abstract：:The studies concerned in vitro migration of peripheral blood lymphocytes of rabbits given intravenously one dose of E. coli lipopolysaccharide (LPS) and antipyretic doses of acetylsalicylic acid (ASA), indomethacin (IND) or mefenamic acid (MEFA). In normothermic animals, ASA appeared to inhibit in vitro the spontaneou...

journal_title：Archivum immunologiae et therapiae experimentalis

authors： Debowy J,Obmińska-Domoradzka B,Switała M,Garbuliński T

更新日期：1985-01-01 00:00:00

abstract：:Alanine aminotransferase activities were tested in erythrocytes of Polish population sample of 213 adults (105 women and 108 men) and 95 children (aging 6 months to 4 years). In the tests a modified method of Wróblewski and Cabaud was used. A significant scatter of enzyme activities was noted, which ranged in adults b...

journal_title：Archivum immunologiae et therapiae experimentalis

authors： Schlesinger D,Hałasa J,Ilnicka A

更新日期：1985-01-01 00:00:00

abstract：:Investigations were carried out on an influence of phospholipids from L. monocytogenes and A. fumigatus on the degradation of Streptococcus faecalis cell walls by mouse peritoneal macrophages. It has been found, that macrophages from mice stimulated with phospholipids under studies degraded streptococcal cell walls la...

journal_title：Archivum immunologiae et therapiae experimentalis

authors： Jakoniuk P,Talarczyk J,Borowski J

更新日期：1985-01-01 00:00:00

abstract：:The carbohydrate and amino acid compositions of the purified Fc receptor from human placental trophoblasts are described. The placental receptor is a glycoprotein. The total content of carbohydrates in the receptor is 30% (w/w). The major carbohydrate components are galactose, N-acetylglucosamine, fucose, and mannose....

journal_title：Archivum immunologiae et therapiae experimentalis

authors： Mikulska J,Lisowski J

更新日期：1985-01-01 00:00:00

abstract：:Antiinflammatory effect of ibuprofen was studied in the model of adjuvant arthritis in rats. Its effectiveness was evaluated on the basis of morphological and biochemical indices. The values of proteolytic and beta-glucuronidase activity in the blood serum were shown to correlate well with clinical exacerbation of adj...

journal_title：Archivum immunologiae et therapiae experimentalis

authors： Pawłowski K

更新日期：1985-01-01 00:00:00

abstract：:Antibacterial, antifungal and antitumor activity of 15 newly synthetized compounds were investigated in vitro. These compounds were mainly 1-[4-pyridyl]-pyridinium salts, dipyridyl sulphides and corresponding sulphones. Antitumor activity was evaluated in a model of leukemia L1210, P388, Sarcoma 180, Ehrlich carcinoma...

journal_title：Archivum immunologiae et therapiae experimentalis

authors： Boduszek B,Wieczorek JS,Mordarski M,Wieczorek J

更新日期：1985-01-01 00:00:00

abstract：:The immunogenicity of trypsinized and radiation-sterilized bovine fascia enriched with pulverized calf cartilage was tested by the regional lymph node blastic cell reaction. The influence of these grafts on the adjacent tissue and on regeneration processes was examined histologically. After transplantation into mice t...

journal_title：Archivum immunologiae et therapiae experimentalis

authors： Komender A,Lesiak-Cyganowska E

更新日期：1984-01-01 00:00:00

abstract：:Haemolytic activity of complement (CH50) and occurrence of circulating immune, complexes (CIC) were studied in serum samples from children with mumps meningitis taken at regular intervals. The decrease of CH50 was observed in 46 out of 77 samples (60%) in the Ist examination, between 1-6th day from the appearance of s...

journal_title：Archivum immunologiae et therapiae experimentalis

authors： Madaliński K,Imbs D,Gregorek H,Jankowski M,Ułanowicz G,Gut W,Kańtoch M

更新日期：1984-01-01 00:00:00

abstract：:Pharmacological activity of 6 newly synthetized water-soluble derivatives of barbiturylo propanosulfonic acids, was evaluated. The compounds were obtained under the conditions of the Ritter reaction. The experiments were performed with the aim to determine the anti-inflammatory and immunotropic activities as well as t...

journal_title：Archivum immunologiae et therapiae experimentalis

authors： Kowalczyk-Bronisz SH

更新日期：1984-01-01 00:00:00

abstract：:C3H mice after transplantation of solid Gardner lymphosarcoma were injected with Methotrexate (MTX) or Alexan. The prolonged survival time of mice treated with antimetabolites was in some cases evidently reduced after an additional injection of Corynebacterium parvum (C.p.). This reduction did not depend on the sequen...

journal_title：Archivum immunologiae et therapiae experimentalis

authors： Motycka K,Chudomel V,Bednár M,Bostík J

更新日期：1984-01-01 00:00:00

abstract：:C4, C3 and C5 levels and the complement hemolytic activity were analysed in 84 ulcerative colitis patients and correlated with activity, extension and duration of the disease, with the presence of extraintestinal manifestation, and with therapeutic effects. The elevation of C3 was observed in both mild active and in s...

journal_title：Archivum immunologiae et therapiae experimentalis

authors： Hermanowicz A,Sliwiński Z,Nawarska Z,Banaś B

更新日期：1984-01-01 00:00:00

abstract：:In our studies on healthy individuals and patients suffering from chronic spastic bronchitis we demonstrated that autologous rosette forming cells in peripheral non-B lymphocytes belong to two subpopulations: HC-sensitive and HC-resistant. In about 50% of individuals there exists only one subpopulation of ARFC-HC-resi...

journal_title：Archivum immunologiae et therapiae experimentalis

authors： Zimecki M,Zwoliński J,Ryzewski J,Wieczorek Z

更新日期：1984-01-01 00:00:00

abstract：:The effect of mice tissue homogenates on the inhibition of granulocyte-macrophage colony formation in vitro was studied. The potent inhibitory activity was displayed by homogenate from liver. The lowest values were found in the kidney and heart. An interrelationship between the rate of inhibition and protein concentra...

journal_title：Archivum immunologiae et therapiae experimentalis

authors： Szmitkowski M,Prokopowicz J,Kondracka E

更新日期：1984-01-01 00:00:00

abstract：:This report presents the results of studies on two membrane markers of lymphocytes isolated from patients with non-Hodgkin's lymphoma. The combined methods were applied allowing for a simultaneous testing of: a) presence of the membrane receptor for mouse erythrocytes (Em) and membrane immunoglobulins (SmIg) or b) pre...

journal_title：Archivum immunologiae et therapiae experimentalis

authors： Krawczyk-Kuliś M,Hołowiecki J,Jarczok K,Duraj M

更新日期：1984-01-01 00:00:00

abstract：:Our studies on the syngeneic immunization with normal cells did not confirm the possibility of induction of alloreactive cytotoxic antibodies in this way. We were not able to induce any antibodies after syngeneic immunizations within BALB/c and BALB/cfC3H strains of mice. Anti-H-2 cytotoxic antibodies were raised by s...

journal_title：Archivum immunologiae et therapiae experimentalis

authors： Opolski A,Radzikowski C

更新日期：1984-01-01 00:00:00

abstract：:The distribution of the fluorescent euchrysine-binding grains in the peripheral and bonmarrow stem cells was estimated in 28 cases of different types of acute leukemia verified according to Lòffler's cytochemical classification. The relationship between the pattern of fluorescent euchrysine-binding grains of human ste...

journal_title：Archivum immunologiae et therapiae experimentalis

authors： Mdzewski B,Tomaszewska Z,Romer B,Rokicka R,Krawczyński J,Kendziorek A,Derulska D

更新日期：1984-01-01 00:00:00

abstract：:Dimeric hybrid protein molecule consisting of disulfide-linked beta (heavy) subunit of haptoglobin (Hp) and L (light) subunit of immunoglobulin G, was synthesized. Molecular mass of the hybrid was 62.0 kd, sedimentation constant B20 = 2.43. Hemoglobin binding activity of the beta X L hybrid as compared with that of na...

journal_title：Archivum immunologiae et therapiae experimentalis

authors： Osada J,Dobryszycka W

更新日期：1984-01-01 00:00:00

abstract：:The present paper discusses the correlation between NDV-induced interferon production and the degree of histamine release from mouse mastocytes. The injection of mice with Newcastle virus was observed to substantially increase the percentage of released histamine and the degree of mastocytes degranulation. A clear-cut...

journal_title：Archivum immunologiae et therapiae experimentalis

authors： Jankowska R,Szalaty H,Małolepszy J

更新日期：1984-01-01 00:00:00

abstract：:Lymphocytes of 6 patients with infectious mononucleosis were found to be capable of responding in mixed lymphocyte culture (MLC) to Epstein-Barr virus (EBV)--transformed lymphoblastoid cell lines and Raji cells, whereas their response to PWM-induced blasts and non-T cells was significantly depressed. This means that d...

journal_title：Archivum immunologiae et therapiae experimentalis

authors： Wasik M,Myc A,Matej H,Rudzka L

更新日期：1983-01-01 00:00:00

abstract：:RNA was labeled with iodine in the reaction catalyzed with lactoperoxidase (LP). Labeling of RNA requires additional purification of LP on Sephadex G-100 and application of RNase inhibitors. Immobilized LP shows lower activity than a soluble enzyme but still it is sufficient to label RNA to 7% IC. Immobilized enzyme i...

journal_title：Archivum immunologiae et therapiae experimentalis

authors： Gładek A,Mordarski M

更新日期：1983-01-01 00:00:00

abstract：:Biological effects of conjugates of quinone derivatives with antibodies were studied. Two methods of conjugation of aziridine derivatives of quinone with anti-L-1210 antibodies were used: the direct substitution of the protein amino groups or thiolation of immunoglobulins and subsequent substitution of the sulfhydryl ...

journal_title：Archivum immunologiae et therapiae experimentalis

authors： Boratyński J,Syper L

更新日期：1983-01-01 00:00:00

abstract：:Wratizolin, the new non-steroidal anti-inflammatory drug, was found to inhibit the replication of Herpes simplex, type 1 and 2, viruses (HSV-1, HSV-2) in vitro. The selectivity of the antiviral action is low because the drug disturbs cellular metabolism. Wratizolin at the relatively low concentration (37 micrograms/ml...

journal_title：Archivum immunologiae et therapiae experimentalis

authors： Inglot AD

更新日期：1983-01-01 00:00:00

abstract：:The examination of patients with Myasthenia gravis revealed that before thymectomy the number of T and B cells in the peripheral blood did not deviate from the norm. It was also observed that their sera contained factor stimulating T lymphocytes to the spontaneous rosette formation, theta antigen generation in xynogen...

journal_title：Archivum immunologiae et therapiae experimentalis

authors： Skibiński G,Ujma B,Guzowski K,Brzecki A,Zwoliński J,Wieczorek Z

更新日期：1983-01-01 00:00:00

abstract：:The HLA typing (A and B loci) was performed in 55 individuals with ankylosing spondylitis (a.s.) in 74 relatives of their families and in 394 normals. HLA B-27 antigen was found in 80% of tested patients with a.s. The relative risk for B-27 being 30.1 and for A2 -- 1.65. In patients with a.s. lacking B-27 antigen the ...

journal_title：Archivum immunologiae et therapiae experimentalis

authors： Konieczna B,Stawarz M,Mackiewicz S

更新日期：1983-01-01 00:00:00

abstract：:Total number of mast cells in popliteal lymph nodes of Balb/c mice is a function of time and Nu gene (complex?) content. The number of mast cells increases with age - in both wild +/+ and in Nu gene (complex?) carriers (Nu/+ and Nu/Nu). The increase in the number of mast cells is faster in the Nu gene carriers than in...

journal_title：Archivum immunologiae et therapiae experimentalis

authors： Włodarski K,Rose NR,Morrison K

更新日期：1983-01-01 00:00:00